Drug interactions
Erythromycin + Pazopanib
Severity: Major
Erythromycin and Pazopanib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-glycoprotein and can raise pazopanib concentrations. Higher exposure increases the risk of hepatotoxicity, hypertension and QT prolongation, which pazopanib itself can cause.
What this interaction means in plain words
Erythromycin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Pazopanib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of pazopanib by erythromycin.
What to do
Prefer a non-interacting antibiotic such as one without CYP3A4 inhibition. If unavoidable, reduce the pazopanib dose per labeling and monitor liver tests, blood pressure and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Erythromycin with Pazopanib?
MediHelp rates the interaction as major. Erythromycin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin inhibits CYP3A4 and P-glycoprotein and can raise pazopanib concentrations. Higher exposure increases the risk of hepatotoxicity, hypertension and QT prolongation, which pazopanib itself can cause.
How serious is the interaction between Erythromycin and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-interacting antibiotic such as one without CYP3A4 inhibition. If unavoidable, reduce the pazopanib dose per labeling and monitor liver tests, blood pressure and ECG.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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