Drug interactions
Erythromycin + Prednisolone
Severity: Minor
Erythromycin and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolides can slightly reduce clearance of corticosteroids, which may increase systemic steroid effects. Prednisolone is affected less than methylprednisolone, and the effect is usually small.
What this interaction means in plain words
Erythromycin and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Prednisolone belongs to Endocrine.
Why it happens
Erythromycin may inhibit P-glycoprotein and CYP3A4, modestly reducing corticosteroid clearance.
What to do
No routine adjustment is needed. Watch for steroid adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Erythromycin with Prednisolone?
MediHelp rates the interaction as minor. Erythromycin and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolides can slightly reduce clearance of corticosteroids, which may increase systemic steroid effects. Prednisolone is affected less than methylprednisolone, and the effect is usually small.
How serious is the interaction between Erythromycin and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for steroid adverse effects during prolonged co-therapy.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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