Drug interactions
Erythromycin + Sorafenib
Severity: Moderate
Erythromycin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Erythromycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and correct potassium and magnesium before and during therapy. Choose a non-QT-prolonging antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Erythromycin with Sorafenib?
MediHelp rates the interaction as moderate. Erythromycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Erythromycin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during therapy. Choose a non-QT-prolonging antibiotic when possible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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