Drug interactions
Erythromycin + Tadalafil
Severity: Moderate
Erythromycin and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin increases tadalafil exposure, which may heighten hypotension, headache, flushing and other adverse effects. The effect is more important at higher or daily doses.
What this interaction means in plain words
Erythromycin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Tadalafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated tadalafil metabolism by erythromycin.
What to do
Use the lowest effective tadalafil dose and follow labeled dose limits for ED with CYP3A4 inhibitors. Monitor blood pressure, especially if the patient takes nitrates or antihypertensives, and note nitrates remain contraindicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Erythromycin with Tadalafil?
MediHelp rates the interaction as moderate. Erythromycin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin increases tadalafil exposure, which may heighten hypotension, headache, flushing and other adverse effects. The effect is more important at higher or daily doses.
How serious is the interaction between Erythromycin and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tadalafil dose and follow labeled dose limits for ED with CYP3A4 inhibitors. Monitor blood pressure, especially if the patient takes nitrates or antihypertensives, and note nitrates remain contraindicated.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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