Drug interactions
Erythromycin base + Eszopiclone
Severity: Moderate
Erythromycin base and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, the main oxidative pathway for eszopiclone, and can raise eszopiclone exposure. This may increase next-day sedation and psychomotor impairment.
What this interaction means in plain words
Erythromycin base and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated eszopiclone metabolism by erythromycin.
What to do
Limit the eszopiclone starting dose to 1 mg at bedtime and monitor for excess sedation or complex sleep behaviors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Erythromycin base with Eszopiclone?
MediHelp rates the interaction as moderate. Erythromycin base and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4, the main oxidative pathway for eszopiclone, and can raise eszopiclone exposure. This may increase next-day sedation and psychomotor impairment.
How serious is the interaction between Erythromycin base and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the eszopiclone starting dose to 1 mg at bedtime and monitor for excess sedation or complex sleep behaviors.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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