Drug interactions
Erythromycin base + Ipratropium-salbutamol
Severity: Moderate
Erythromycin base and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and can cause torsades de pointes. Salbutamol may add to this risk, especially at high doses or with hypokalemia. Erythromycin may also modestly raise beta-agonist exposure.
What this interaction means in plain words
Erythromycin base and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia increasing proarrhythmic risk.
What to do
Check potassium and magnesium and consider an ECG in patients with other QT risk factors. Prefer a non-QT-prolonging antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Erythromycin base with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Erythromycin base and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval and can cause torsades de pointes. Salbutamol may add to this risk, especially at high doses or with hypokalemia. Erythromycin may also modestly raise beta-agonist exposure.
How serious is the interaction between Erythromycin base and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and consider an ECG in patients with other QT risk factors. Prefer a non-QT-prolonging antibiotic when feasible.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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