Drug interactions
Erythromycin base + Tamsulosin
Severity: Moderate
Erythromycin base and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may raise tamsulosin levels. This can increase orthostatic hypotension and dizziness.
What this interaction means in plain words
Erythromycin base and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces tamsulosin metabolism.
What to do
Monitor for hypotension and dizziness during the antibiotic course. Consider a temporary tamsulosin dose reduction in susceptible patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Erythromycin base with Tamsulosin?
MediHelp rates the interaction as moderate. Erythromycin base and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and may raise tamsulosin levels. This can increase orthostatic hypotension and dizziness.
How serious is the interaction between Erythromycin base and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypotension and dizziness during the antibiotic course. Consider a temporary tamsulosin dose reduction in susceptible patients.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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