Drug interactions
Erythromycin base + Tinidazole
Severity: Minor
Erythromycin base and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may modestly increase tinidazole concentrations. Both drugs can cause gastrointestinal upset, and the combination may increase this effect.
What this interaction means in plain words
Erythromycin base and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated tinidazole metabolism by erythromycin.
What to do
No dose change is usually needed; monitor for gastrointestinal and neurological adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Erythromycin base with Tinidazole?
MediHelp rates the interaction as minor. Erythromycin base and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may modestly increase tinidazole concentrations. Both drugs can cause gastrointestinal upset, and the combination may increase this effect.
How serious is the interaction between Erythromycin base and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for gastrointestinal and neurological adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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