Drug interactions
Erythromycin ethylsuccinate + Flecainide
Severity: Moderate
Erythromycin ethylsuccinate and Flecainide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and flecainide can add to conduction and repolarization effects. The combination raises the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Erythromycin ethylsuccinate and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through cardiac potassium and sodium channel effects.
What to do
Consider an alternative antibiotic with less QT effect. If used together, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Flecainide?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval and flecainide can add to conduction and repolarization effects. The combination raises the risk of serious ventricular arrhythmias.
How serious is the interaction between Erythromycin ethylsuccinate and Flecainide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic with less QT effect. If used together, monitor ECG and correct potassium and magnesium.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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