Drug interactions
Erythromycin ethylsuccinate + Fluticasone-vilanterol
Severity: Moderate
Erythromycin ethylsuccinate and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise vilanterol and fluticasone furoate exposure, and it also prolongs the QT interval. This may increase beta-agonist cardiovascular effects and arrhythmia risk.
What this interaction means in plain words
Erythromycin ethylsuccinate and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition increasing vilanterol exposure, plus additive QT prolongation.
What to do
Monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Consider an azithromycin alternative if a macrolide is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise vilanterol and fluticasone furoate exposure, and it also prolongs the QT interval. This may increase beta-agonist cardiovascular effects and arrhythmia risk.
How serious is the interaction between Erythromycin ethylsuccinate and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Consider an azithromycin alternative if a macrolide is needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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