Drug interactions
Erythromycin ethylsuccinate + Nicardipine
Severity: Moderate
Erythromycin ethylsuccinate and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can increase nicardipine concentrations. Patients may experience hypotension, flushing, headache and edema.
What this interaction means in plain words
Erythromycin ethylsuccinate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4, reducing nicardipine metabolism.
What to do
Monitor blood pressure and heart rate and reduce the nicardipine dose if hypotension occurs. Consider azithromycin as an alternative macrolide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Nicardipine?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can increase nicardipine concentrations. Patients may experience hypotension, flushing, headache and edema.
How serious is the interaction between Erythromycin ethylsuccinate and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the nicardipine dose if hypotension occurs. Consider azithromycin as an alternative macrolide.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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