Drug interactions
Erythromycin ethylsuccinate + Rosuvastatin
Severity: Minor
Erythromycin ethylsuccinate and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly alter rosuvastatin exposure, and the clinical effect is generally small. Rosuvastatin is minimally metabolized by CYP3A4, so the interaction is far weaker than with other statins.
What this interaction means in plain words
Erythromycin ethylsuccinate and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin may weakly inhibit OATP1B1-mediated hepatic uptake of rosuvastatin.
What to do
No dose change is usually needed; advise patients to report muscle pain or weakness during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Rosuvastatin?
MediHelp rates the interaction as minor. Erythromycin ethylsuccinate and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may modestly alter rosuvastatin exposure, and the clinical effect is generally small. Rosuvastatin is minimally metabolized by CYP3A4, so the interaction is far weaker than with other statins.
How serious is the interaction between Erythromycin ethylsuccinate and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; advise patients to report muscle pain or weakness during the antibiotic course.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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