Drug interactions
Erythromycin stearate + Prednisone
Severity: Minor
Erythromycin stearate and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may modestly reduce clearance of corticosteroids, with greater effect on methylprednisolone than prednisolone. Increased systemic corticosteroid effects are possible but usually minor.
What this interaction means in plain words
Erythromycin stearate and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4-mediated corticosteroid metabolism.
What to do
No routine adjustment is needed; monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Erythromycin stearate with Prednisone?
MediHelp rates the interaction as minor. Erythromycin stearate and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may modestly reduce clearance of corticosteroids, with greater effect on methylprednisolone than prednisolone. Increased systemic corticosteroid effects are possible but usually minor.
How serious is the interaction between Erythromycin stearate and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention during prolonged co-therapy.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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