Drug interactions
Erythromycin stearate + Zafirlukast
Severity: Minor
Erythromycin stearate and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is only a weak CYP3A4 inhibitor, so a meaningful rise in erythromycin exposure is unlikely. Erythromycin has been reported to modestly lower zafirlukast levels, with limited clinical consequence.
What this interaction means in plain words
Erythromycin stearate and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible minor CYP3A4-related pharmacokinetic effects; erythromycin may reduce zafirlukast bioavailability.
What to do
No routine adjustment is needed; monitor asthma control if both drugs are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Erythromycin stearate with Zafirlukast?
MediHelp rates the interaction as minor. Erythromycin stearate and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast is only a weak CYP3A4 inhibitor, so a meaningful rise in erythromycin exposure is unlikely. Erythromycin has been reported to modestly lower zafirlukast levels, with limited clinical consequence.
How serious is the interaction between Erythromycin stearate and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor asthma control if both drugs are used together.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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