Drug interactions
Escitalopram + Etodolac
Severity: Moderate
Escitalopram and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining etodolac with escitalopram increases the risk of upper gastrointestinal bleeding compared with either drug alone, especially in older patients or those with ulcer history.
What this interaction means in plain words
Escitalopram and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Etodolac belongs to Musculoskeletal.
Why it happens
SSRI-induced depletion of platelet serotonin impairs aggregation, adding to NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid if possible; otherwise add a proton pump inhibitor and monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Etodolac?
MediHelp rates the interaction as moderate. Escitalopram and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining etodolac with escitalopram increases the risk of upper gastrointestinal bleeding compared with either drug alone, especially in older patients or those with ulcer history.
How serious is the interaction between Escitalopram and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise add a proton pump inhibitor and monitor for signs of GI bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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