Drug interactions
Escitalopram + Gabapentin enacarbil
Severity: Minor
Escitalopram and Gabapentin enacarbil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil causes sedation and dizziness, which may add to similar effects of escitalopram. The respiratory depression warnings for gabapentinoids apply mainly with opioids or other strong depressants, so the risk with an SSRI is low.
What this interaction means in plain words
Escitalopram and Gabapentin enacarbil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel patients about drowsiness and dizziness and caution with driving. Reduce the gabapentin enacarbil dose if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Escitalopram with Gabapentin enacarbil?
MediHelp rates the interaction as minor. Escitalopram and Gabapentin enacarbil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentin enacarbil causes sedation and dizziness, which may add to similar effects of escitalopram. The respiratory depression warnings for gabapentinoids apply mainly with opioids or other strong depressants, so the risk with an SSRI is low.
How serious is the interaction between Escitalopram and Gabapentin enacarbil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and dizziness and caution with driving. Reduce the gabapentin enacarbil dose if sedation is troublesome.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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