Drug interactions
Escitalopram + Histrelin
Severity: Moderate
Escitalopram and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist causing androgen deprivation, may prolong the QT interval, and escitalopram adds to this effect. The combination may increase the risk of torsades de pointes, particularly in patients with cardiac risk factors.
What this interaction means in plain words
Escitalopram and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation; androgen deprivation therapy is associated with QT lengthening.
What to do
Obtain a baseline ECG and correct electrolytes, then monitor the QTc, particularly with other QT-prolonging drugs or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Escitalopram with Histrelin?
MediHelp rates the interaction as moderate. Escitalopram and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist causing androgen deprivation, may prolong the QT interval, and escitalopram adds to this effect. The combination may increase the risk of torsades de pointes, particularly in patients with cardiac risk factors.
How serious is the interaction between Escitalopram and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes, then monitor the QTc, particularly with other QT-prolonging drugs or cardiac disease.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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