Drug interactions
Escitalopram + Lenacapavir
Severity: Minor
Escitalopram and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir moderately inhibits CYP3A4, which contributes to escitalopram metabolism. Escitalopram exposure may rise modestly. The effect is likely small because CYP2C19 and CYP2D6 also clear escitalopram.
What this interaction means in plain words
Escitalopram and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated escitalopram metabolism by lenacapavir.
What to do
No dose change is usually needed. Monitor for dose-related adverse effects such as nausea, somnolence and QT prolongation, especially at higher escitalopram doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Escitalopram with Lenacapavir?
MediHelp rates the interaction as minor. Escitalopram and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir moderately inhibits CYP3A4, which contributes to escitalopram metabolism. Escitalopram exposure may rise modestly. The effect is likely small because CYP2C19 and CYP2D6 also clear escitalopram.
How serious is the interaction between Escitalopram and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for dose-related adverse effects such as nausea, somnolence and QT prolongation, especially at higher escitalopram doses.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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