Drug interactions
Escitalopram + Oxaprozin
Severity: Major
Escitalopram and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Escitalopram combined with an NSAID increases the risk of upper gastrointestinal bleeding beyond either drug alone. Older adults and those with prior ulcers are most at risk.
What this interaction means in plain words
Escitalopram and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Escitalopram belongs to Central Nervous System; Oxaprozin belongs to Musculoskeletal.
Why it happens
SSRI-mediated depletion of platelet serotonin impairs aggregation, adding to NSAID antiplatelet and mucosal-damaging effects.
What to do
Avoid combination where possible, or co-prescribe a proton pump inhibitor and monitor for signs of GI bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Oxaprozin?
MediHelp rates the interaction as major. Escitalopram and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Escitalopram combined with an NSAID increases the risk of upper gastrointestinal bleeding beyond either drug alone. Older adults and those with prior ulcers are most at risk.
How serious is the interaction between Escitalopram and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible, or co-prescribe a proton pump inhibitor and monitor for signs of GI bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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