Drug interactions
Escitalopram + Sulindac
Severity: Major
Escitalopram and Sulindac: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID raises the risk of upper gastrointestinal bleeding compared with either drug alone. Risk is higher in older adults and patients with prior ulcers or on anticoagulants.
What this interaction means in plain words
Escitalopram and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Escitalopram belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
SSRI-induced platelet serotonin depletion impairs aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Avoid if possible; otherwise prescribe a proton pump inhibitor and monitor for GI bleeding and anemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Sulindac?
MediHelp rates the interaction as major. Escitalopram and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an SSRI with an NSAID raises the risk of upper gastrointestinal bleeding compared with either drug alone. Risk is higher in older adults and patients with prior ulcers or on anticoagulants.
How serious is the interaction between Escitalopram and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise prescribe a proton pump inhibitor and monitor for GI bleeding and anemia.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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