Drug interactions
Escitalopram + Voclosporin
Severity: Moderate
Escitalopram and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and escitalopram prolongs the QT interval in a dose-related manner. Using both may add to the arrhythmia risk, especially with electrolyte disturbances.
What this interaction means in plain words
Escitalopram and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG in patients with additional QT risk factors and keep potassium and magnesium within normal range. Limit the escitalopram dose in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Escitalopram with Voclosporin?
MediHelp rates the interaction as moderate. Escitalopram and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and escitalopram prolongs the QT interval in a dose-related manner. Using both may add to the arrhythmia risk, especially with electrolyte disturbances.
How serious is the interaction between Escitalopram and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with additional QT risk factors and keep potassium and magnesium within normal range. Limit the escitalopram dose in higher-risk patients.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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