Drug interactions
Esketamine + Levetiracetam
Severity: Minor
Esketamine and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam commonly causes somnolence and dizziness, which may add to esketamine's sedation. Behavioral side effects may also be more noticeable.
What this interaction means in plain words
Esketamine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for increased sedation or dizziness after esketamine administration and advise against driving until the next day.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Levetiracetam
Frequently asked questions
Can I take Esketamine with Levetiracetam?
MediHelp rates the interaction as minor. Esketamine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levetiracetam commonly causes somnolence and dizziness, which may add to esketamine's sedation. Behavioral side effects may also be more noticeable.
How serious is the interaction between Esketamine and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or dizziness after esketamine administration and advise against driving until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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