Drug interactions
Esketamine + Levocetirizine
Severity: Minor
Esketamine and Levocetirizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levocetirizine is a second-generation antihistamine that causes drowsiness in some patients. Combined with esketamine it may modestly increase sedation, though the clinical effect is usually small.
What this interaction means in plain words
Esketamine and Levocetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Levocetirizine belongs to Respiratory.
Why it happens
Additive CNS depressant effects from H1-antihistamine sedation and esketamine.
What to do
Advise patients that drowsiness may be greater on treatment days. Monitor sedation during the post-dose observation period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Levocetirizine
Frequently asked questions
Can I take Esketamine with Levocetirizine?
MediHelp rates the interaction as minor. Esketamine and Levocetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levocetirizine is a second-generation antihistamine that causes drowsiness in some patients. Combined with esketamine it may modestly increase sedation, though the clinical effect is usually small.
How serious is the interaction between Esketamine and Levocetirizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients that drowsiness may be greater on treatment days. Monitor sedation during the post-dose observation period.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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