Drug interactions
Esketamine + Maprotiline
Severity: Moderate
Esketamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine and the sedating tetracyclic antidepressant maprotiline both cause drowsiness. Combined use may increase sedation and impair attention and coordination. Maprotiline also lowers the seizure threshold, which adds to the concern.
What this interaction means in plain words
Esketamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from esketamine and maprotiline's antihistaminic and sedative properties.
What to do
Monitor sedation during and after esketamine sessions and advise against driving until the next day. Reassess the maprotiline dose if oversedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Esketamine with Maprotiline?
MediHelp rates the interaction as moderate. Esketamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine and the sedating tetracyclic antidepressant maprotiline both cause drowsiness. Combined use may increase sedation and impair attention and coordination. Maprotiline also lowers the seizure threshold, which adds to the concern.
How serious is the interaction between Esketamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during and after esketamine sessions and advise against driving until the next day. Reassess the maprotiline dose if oversedation develops.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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