Drug interactions
Esketamine + Metaxalone
Severity: Moderate
Esketamine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a centrally acting muscle relaxant that commonly causes drowsiness and dizziness. Used with esketamine it may increase sedation and impair alertness.
What this interaction means in plain words
Esketamine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from centrally acting muscle relaxation and esketamine sedation.
What to do
Monitor sedation after dosing and advise against driving until the next day. Consider holding the muscle relaxant on treatment days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Metaxalone
Frequently asked questions
Can I take Esketamine with Metaxalone?
MediHelp rates the interaction as moderate. Esketamine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a centrally acting muscle relaxant that commonly causes drowsiness and dizziness. Used with esketamine it may increase sedation and impair alertness.
How serious is the interaction between Esketamine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after dosing and advise against driving until the next day. Consider holding the muscle relaxant on treatment days.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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