Drug interactions
Esketamine + Methocarbamol
Severity: Moderate
Esketamine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol is a centrally acting muscle relaxant that can cause drowsiness and dizziness. Combined with esketamine it may increase sedation and psychomotor impairment.
What this interaction means in plain words
Esketamine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from muscle relaxant sedation and esketamine.
What to do
Monitor sedation during post-dose observation. Advise patients to avoid taking methocarbamol shortly before sessions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Methocarbamol
Frequently asked questions
Can I take Esketamine with Methocarbamol?
MediHelp rates the interaction as moderate. Esketamine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methocarbamol is a centrally acting muscle relaxant that can cause drowsiness and dizziness. Combined with esketamine it may increase sedation and psychomotor impairment.
How serious is the interaction between Esketamine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during post-dose observation. Advise patients to avoid taking methocarbamol shortly before sessions.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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