Drug interactions
Esketamine + Oliceridine
Severity: Major
Esketamine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an intravenous opioid, and with esketamine it can increase sedation, hypotension and respiratory depression. The combination needs more caution than either drug alone.
What this interaction means in plain words
Esketamine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Esketamine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and NMDA antagonism.
What to do
Titrate oliceridine to the lowest effective dose and monitor sedation, respiratory rate and oxygen saturation continuously. Reduce doses in frail patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Esketamine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Esketamine with Oliceridine?
MediHelp rates the interaction as major. Esketamine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an intravenous opioid, and with esketamine it can increase sedation, hypotension and respiratory depression. The combination needs more caution than either drug alone.
How serious is the interaction between Esketamine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to the lowest effective dose and monitor sedation, respiratory rate and oxygen saturation continuously. Reduce doses in frail patients.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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