Drug interactions
Esketamine + Ramelteon
Severity: Minor
Esketamine and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon has mild sedative effects and may slightly add to drowsiness from esketamine. The clinical effect is generally small.
What this interaction means in plain words
Esketamine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive CNS depression via melatonin receptor agonism and NMDA antagonism.
What to do
No dose change is usually needed; monitor sedation during the post-dose observation period. Advise against driving until the next day.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Esketamine with Ramelteon?
MediHelp rates the interaction as minor. Esketamine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon has mild sedative effects and may slightly add to drowsiness from esketamine. The clinical effect is generally small.
How serious is the interaction between Esketamine and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor sedation during the post-dose observation period. Advise against driving until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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