Drug interactions
Esketamine + Ziprasidone
Severity: Moderate
Esketamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone causes sedation and QT prolongation, and with esketamine can increase drowsiness. Esketamine-related changes in heart rate and blood pressure add to cardiovascular stress.
What this interaction means in plain words
Esketamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziprasidone prolongs QT via hERG blockade.
What to do
Monitor sedation and blood pressure, and obtain an ECG in patients with cardiac risk factors or electrolyte disturbance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Esketamine with Ziprasidone?
MediHelp rates the interaction as moderate. Esketamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone causes sedation and QT prolongation, and with esketamine can increase drowsiness. Esketamine-related changes in heart rate and blood pressure add to cardiovascular stress.
How serious is the interaction between Esketamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and obtain an ECG in patients with cardiac risk factors or electrolyte disturbance.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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