Drug interactions
Esketamine intranasal + Eszopiclone
Severity: Moderate
Esketamine intranasal and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and dizziness, and a hypnotic taken around the same time may add to these effects. Patients may have greater impairment and reduced alertness after dosing.
What this interaction means in plain words
Esketamine intranasal and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Avoid taking eszopiclone before esketamine sessions and monitor sedation during the post-dose observation period. Advise against driving until the next day after sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Esketamine intranasal with Eszopiclone?
MediHelp rates the interaction as moderate. Esketamine intranasal and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and dizziness, and a hypnotic taken around the same time may add to these effects. Patients may have greater impairment and reduced alertness after dosing.
How serious is the interaction between Esketamine intranasal and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking eszopiclone before esketamine sessions and monitor sedation during the post-dose observation period. Advise against driving until the next day after sleep.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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