Drug interactions
Esketamine intranasal + Levetiracetam
Severity: Moderate
Esketamine intranasal and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and impaired cognition, and levetiracetam may add to drowsiness. Together they may increase impairment after dosing.
What this interaction means in plain words
Esketamine intranasal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of an NMDA antagonist and an antiepileptic.
What to do
Monitor patients for sedation during the required post-dose observation period. Advise no driving until the next day after a restful sleep, as for esketamine alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Esketamine intranasal with Levetiracetam?
MediHelp rates the interaction as moderate. Esketamine intranasal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and impaired cognition, and levetiracetam may add to drowsiness. Together they may increase impairment after dosing.
How serious is the interaction between Esketamine intranasal and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for sedation during the required post-dose observation period. Advise no driving until the next day after a restful sleep, as for esketamine alone.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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