Drug interactions
Esketamine intranasal + Levocetirizine
Severity: Minor
Esketamine intranasal and Levocetirizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and levocetirizine can add mild sedation. The combination may increase drowsiness, though the extra effect from a second-generation antihistamine is usually small.
What this interaction means in plain words
Esketamine intranasal and Levocetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects.
What to do
Observe the patient for sedation during the esketamine post-dose monitoring period. Advise against driving until the day after treatment, as already required with esketamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levocetirizine
Frequently asked questions
Can I take Esketamine intranasal with Levocetirizine?
MediHelp rates the interaction as minor. Esketamine intranasal and Levocetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esketamine causes sedation and dissociation, and levocetirizine can add mild sedation. The combination may increase drowsiness, though the extra effect from a second-generation antihistamine is usually small.
How serious is the interaction between Esketamine intranasal and Levocetirizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient for sedation during the esketamine post-dose monitoring period. Advise against driving until the day after treatment, as already required with esketamine.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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