Drug interactions
Esketamine intranasal + Quetiapine
Severity: Moderate
Esketamine intranasal and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, and using them together can deepen drowsiness and impair psychomotor performance. Esketamine can also raise blood pressure, adding to the cardiovascular burden in some patients.
What this interaction means in plain words
Esketamine intranasal and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects through different receptor pathways.
What to do
Monitor sedation and blood pressure for at least the post-dose observation period after each esketamine session. Advise patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Esketamine intranasal with Quetiapine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, and using them together can deepen drowsiness and impair psychomotor performance. Esketamine can also raise blood pressure, adding to the cardiovascular burden in some patients.
How serious is the interaction between Esketamine intranasal and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure for at least the post-dose observation period after each esketamine session. Advise patients not to drive until the next day after a restful sleep.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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