Drug interactions
Esketamine intranasal + Ziprasidone
Severity: Moderate
Esketamine intranasal and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and ziprasidone is also sedating. The combination may cause additive drowsiness and impaired psychomotor function, and esketamine can raise blood pressure.
What this interaction means in plain words
Esketamine intranasal and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation and blood pressure for at least two hours after each esketamine dose. Advise patients not to drive until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Ziprasidone?
MediHelp rates the interaction as moderate. Esketamine intranasal and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and ziprasidone is also sedating. The combination may cause additive drowsiness and impaired psychomotor function, and esketamine can raise blood pressure.
How serious is the interaction between Esketamine intranasal and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure for at least two hours after each esketamine dose. Advise patients not to drive until the next day.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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