Drug interactions
Estazolam + Oxymorphone
Severity: Major
Estazolam and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a benzodiazepine produces additive sedation, respiratory depression, coma and death. Regulators carry boxed warnings for this combination, and the risk is highest at higher doses and in opioid-naive, elderly or respiratory-compromised patients.
What this interaction means in plain words
Estazolam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through mu-opioid receptor agonism and GABA-A receptor potentiation.
What to do
Avoid the combination where possible; if it is necessary, use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Consider naloxone availability and counsel the patient about driving and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Estazolam with Oxymorphone?
MediHelp rates the interaction as major. Estazolam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine produces additive sedation, respiratory depression, coma and death. Regulators carry boxed warnings for this combination, and the risk is highest at higher doses and in opioid-naive, elderly or respiratory-compromised patients.
How serious is the interaction between Estazolam and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Consider naloxone availability and counsel the patient about driving and alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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