Drug interactions
Estazolam + Ramelteon
Severity: Moderate
Estazolam and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a benzodiazepine hypnotic, and combined with ramelteon may produce additive sedation and impaired next-day psychomotor function. Use of two hypnotics raises falls risk, particularly in older adults.
What this interaction means in plain words
Estazolam and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and melatonin receptor agonism.
What to do
Avoid routine concurrent use of two hypnotics; if combined, use the lowest doses and monitor for daytime sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Estazolam with Ramelteon?
MediHelp rates the interaction as moderate. Estazolam and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a benzodiazepine hypnotic, and combined with ramelteon may produce additive sedation and impaired next-day psychomotor function. Use of two hypnotics raises falls risk, particularly in older adults.
How serious is the interaction between Estazolam and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two hypnotics; if combined, use the lowest doses and monitor for daytime sedation and falls.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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