Drug interactions
Estradiol vaginal + Verapamil
Severity: Minor
Estradiol vaginal and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and could modestly raise estradiol exposure. With low-dose vaginal estradiol, systemic exposure is small, so the effect is unlikely to matter clinically.
What this interaction means in plain words
Estradiol vaginal and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak to moderate inhibition of CYP3A4-mediated estradiol metabolism by verapamil.
What to do
No routine action is needed; consider reviewing estrogenic adverse effects such as breast tenderness or bleeding if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Estradiol vaginal with Verapamil?
MediHelp rates the interaction as minor. Estradiol vaginal and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 and could modestly raise estradiol exposure. With low-dose vaginal estradiol, systemic exposure is small, so the effect is unlikely to matter clinically.
How serious is the interaction between Estradiol vaginal and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider reviewing estrogenic adverse effects such as breast tenderness or bleeding if symptoms appear.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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