Drug interactions
Estrogens conjugated synthetic + Metyrapone
Severity: Minor
Estrogens conjugated synthetic and Metyrapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens raise cortisol-binding globulin and total cortisol, which can distort the interpretation of the metyrapone test, and a reduced response has been described. Synthetic conjugated estrogens may therefore reduce the apparent response to metyrapone.
What this interaction means in plain words
Estrogens conjugated synthetic and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogen-induced rise in cortisol-binding globulin alters cortisol measurements; the exact mechanism for reduced metyrapone response is not firmly established.
What to do
When metyrapone is used diagnostically, consider holding estrogens beforehand or interpret results with the estrogen effect in mind. During treatment, monitor free cortisol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Estrogens conjugated synthetic with Metyrapone?
MediHelp rates the interaction as minor. Estrogens conjugated synthetic and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens raise cortisol-binding globulin and total cortisol, which can distort the interpretation of the metyrapone test, and a reduced response has been described. Synthetic conjugated estrogens may therefore reduce the apparent response to metyrapone.
How serious is the interaction between Estrogens conjugated synthetic and Metyrapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When metyrapone is used diagnostically, consider holding estrogens beforehand or interpret results with the estrogen effect in mind. During treatment, monitor free cortisol.
What other medicines interact with Metyrapone?
MediHelp also lists interactions of Metyrapone with, for example, Pacritinib, Budesonide, Cortisone. The full list is on the Metyrapone page.
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