Drug interactions
Estrogens conjugated synthetic + Mifepristone
Severity: Moderate
Estrogens conjugated synthetic and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which may raise exposure to synthetic conjugated estrogens. Higher estrogen levels could increase estrogen-related adverse effects. Mifepristone also has antiprogestogenic and antiglucocorticoid activity that may be relevant in women with an intact uterus.
What this interaction means in plain words
Estrogens conjugated synthetic and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone inhibits CYP3A4-mediated estrogen metabolism, raising estrogen exposure.
What to do
Monitor for estrogenic adverse effects such as breast tenderness, fluid retention and abnormal bleeding. Reduce the estrogen dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Estrogens conjugated synthetic with Mifepristone?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, which may raise exposure to synthetic conjugated estrogens. Higher estrogen levels could increase estrogen-related adverse effects. Mifepristone also has antiprogestogenic and antiglucocorticoid activity that may be relevant in women with an intact uterus.
How serious is the interaction between Estrogens conjugated synthetic and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as breast tenderness, fluid retention and abnormal bleeding. Reduce the estrogen dose if symptoms occur.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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