Drug interactions
Estrogens conjugated synthetic + Prednisone
Severity: Minor
Estrogens conjugated synthetic and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens can increase prednisolone exposure by lowering its clearance and raising binding protein levels, so corticosteroid effects may be amplified. Reduced estrogen effect from prednisone is not clinically supported.
What this interaction means in plain words
Estrogens conjugated synthetic and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens reduce hepatic clearance of prednisolone and increase corticosteroid-binding globulin.
What to do
Monitor for excess corticosteroid effects and lower the prednisone dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Estrogens conjugated synthetic with Prednisone?
MediHelp rates the interaction as minor. Estrogens conjugated synthetic and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens can increase prednisolone exposure by lowering its clearance and raising binding protein levels, so corticosteroid effects may be amplified. Reduced estrogen effect from prednisone is not clinically supported.
How serious is the interaction between Estrogens conjugated synthetic and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess corticosteroid effects and lower the prednisone dose if they occur.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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