Drug interactions
Estrogens conjugated synthetic + Verapamil
Severity: Minor
Estrogens conjugated synthetic and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may modestly raise estrogen exposure, which could increase estrogenic adverse effects like breast tenderness, nausea or breakthrough bleeding. The effect is expected to be small.
What this interaction means in plain words
Estrogens conjugated synthetic and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Verapamil inhibits CYP3A4 and P-glycoprotein, potentially decreasing estrogen metabolism and efflux.
What to do
No routine adjustment is needed; reduce the estrogen dose if estrogen-related adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Estrogens conjugated synthetic with Verapamil?
MediHelp rates the interaction as minor. Estrogens conjugated synthetic and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may modestly raise estrogen exposure, which could increase estrogenic adverse effects like breast tenderness, nausea or breakthrough bleeding. The effect is expected to be small.
How serious is the interaction between Estrogens conjugated synthetic and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reduce the estrogen dose if estrogen-related adverse effects develop.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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