Drug interactions
Estrogens esterified + Verapamil
Severity: Minor
Estrogens esterified and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may slightly increase circulating estrogen concentrations. Clinically this might show as breast tenderness, headache or bleeding changes, but significant effects are unlikely.
What this interaction means in plain words
Estrogens esterified and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Verapamil inhibits CYP3A4, which participates in estrogen metabolism.
What to do
No routine action is needed; review for estrogenic adverse effects and adjust the estrogen dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Estrogens esterified with Verapamil?
MediHelp rates the interaction as minor. Estrogens esterified and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may slightly increase circulating estrogen concentrations. Clinically this might show as breast tenderness, headache or bleeding changes, but significant effects are unlikely.
How serious is the interaction between Estrogens esterified and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; review for estrogenic adverse effects and adjust the estrogen dose if they occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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