Drug interactions
Eszopiclone + Fentanyl iontophoretic transdermal system
Severity: Major
Eszopiclone and Fentanyl iontophoretic transdermal system: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedative-hypnotics can cause profound sedation, respiratory depression, coma and death. Labeling for opioids warns about this combination.
What this interaction means in plain words
Eszopiclone and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid and GABAergic pathways.
What to do
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration, and monitor for respiratory depression and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as major. Eszopiclone and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with sedative-hypnotics can cause profound sedation, respiratory depression, coma and death. Labeling for opioids warns about this combination.
How serious is the interaction between Eszopiclone and Fentanyl iontophoretic transdermal system?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration, and monitor for respiratory depression and sedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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