Drug interactions
Eszopiclone + Fosphenytoin
Severity: Moderate
Eszopiclone and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin, via its active metabolite phenytoin, induces CYP3A4 and may reduce eszopiclone exposure and effectiveness. Additive sedation can also occur.
What this interaction means in plain words
Eszopiclone and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induction of CYP3A4 increases eszopiclone clearance.
What to do
Monitor for reduced hypnotic effect and adjust the eszopiclone dose if needed; also watch for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Eszopiclone with Fosphenytoin?
MediHelp rates the interaction as moderate. Eszopiclone and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin, via its active metabolite phenytoin, induces CYP3A4 and may reduce eszopiclone exposure and effectiveness. Additive sedation can also occur.
How serious is the interaction between Eszopiclone and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic effect and adjust the eszopiclone dose if needed; also watch for sedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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