Drug interactions
Eszopiclone + Gabapentin
Severity: Moderate
Eszopiclone and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and together they can cause marked sedation, impaired psychomotor function and respiratory depression. The risk is higher in older patients, those with lung disease, and at higher doses.
What this interaction means in plain words
Eszopiclone and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from GABA-A agonism (eszopiclone) and gabapentin's calcium channel effects.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and in patients with respiratory compromise. Advise avoiding alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Gabapentin
Frequently asked questions
Can I take Eszopiclone with Gabapentin?
MediHelp rates the interaction as moderate. Eszopiclone and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and together they can cause marked sedation, impaired psychomotor function and respiratory depression. The risk is higher in older patients, those with lung disease, and at higher doses.
How serious is the interaction between Eszopiclone and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and in patients with respiratory compromise. Advise avoiding alcohol and other sedatives.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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