Drug interactions
Eszopiclone + Metoclopramide intranasal
Severity: Moderate
Eszopiclone and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness, dizziness and extrapyramidal or other CNS effects, which may add to eszopiclone sedation and impairment.
What this interaction means in plain words
Eszopiclone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; central dopamine antagonism by metoclopramide adds to sedation.
What to do
Avoid taking eszopiclone with metoclopramide when feasible. Monitor for excess sedation and warn against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Eszopiclone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness, dizziness and extrapyramidal or other CNS effects, which may add to eszopiclone sedation and impairment.
How serious is the interaction between Eszopiclone and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking eszopiclone with metoclopramide when feasible. Monitor for excess sedation and warn against driving.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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