Drug interactions
Eszopiclone + Midazolam intranasal
Severity: Major
Eszopiclone and Midazolam intranasal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedative-hypnotic with midazolam can produce additive sedation and respiratory depression, including hypoventilation, airway obstruction and apnea. The effect may be profound or prolonged.
What this interaction means in plain words
Eszopiclone and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A receptor modulation by both drugs.
What to do
Avoid combined use where possible, or reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness. Make sure resuscitation equipment is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Midazolam intranasal?
MediHelp rates the interaction as major. Eszopiclone and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedative-hypnotic with midazolam can produce additive sedation and respiratory depression, including hypoventilation, airway obstruction and apnea. The effect may be profound or prolonged.
How serious is the interaction between Eszopiclone and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible, or reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness. Make sure resuscitation equipment is available.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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