Drug interactions
Eszopiclone + Olanzapine / samidorphan
Severity: Moderate
Eszopiclone and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes sedation and orthostatic hypotension, and eszopiclone may add to these effects. This raises the risk of falls and impaired alertness.
What this interaction means in plain words
Eszopiclone and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor for sedation and orthostatic symptoms and use the lowest effective eszopiclone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eszopiclone and Olanzapine / samidorphan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Eszopiclone and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes sedation and orthostatic hypotension, and eszopiclone may add to these effects. This raises the risk of falls and impaired alertness.
How serious is the interaction between Eszopiclone and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms and use the lowest effective eszopiclone dose.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
