Drug interactions
Eszopiclone + Phenobarbital
Severity: Moderate
Eszopiclone and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and may reduce eszopiclone concentrations and efficacy. Phenobarbital is also itself a CNS depressant, so sedation can be additive.
What this interaction means in plain words
Eszopiclone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by phenobarbital increases eszopiclone clearance, plus additive CNS depression.
What to do
Monitor for reduced hypnotic response and for additive sedation. Consider an alternative hypnotic if effect is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Phenobarbital?
MediHelp rates the interaction as moderate. Eszopiclone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and may reduce eszopiclone concentrations and efficacy. Phenobarbital is also itself a CNS depressant, so sedation can be additive.
How serious is the interaction between Eszopiclone and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic response and for additive sedation. Consider an alternative hypnotic if effect is inadequate.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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