Drug interactions
Eszopiclone + Rifampin
Severity: Moderate
Eszopiclone and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent CYP3A4 inducer and substantially lowers exposure to zopiclone, the racemate of eszopiclone. Eszopiclone is likely to lose efficacy, causing insomnia treatment failure.
What this interaction means in plain words
Eszopiclone and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases eszopiclone clearance.
What to do
Monitor for loss of hypnotic effect and consider a higher eszopiclone dose within labeled limits or an alternative hypnotic. Reassess the dose when rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Rifampin?
MediHelp rates the interaction as moderate. Eszopiclone and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent CYP3A4 inducer and substantially lowers exposure to zopiclone, the racemate of eszopiclone. Eszopiclone is likely to lose efficacy, causing insomnia treatment failure.
How serious is the interaction between Eszopiclone and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hypnotic effect and consider a higher eszopiclone dose within labeled limits or an alternative hypnotic. Reassess the dose when rifampin is stopped.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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